Can a personalized diet help improve health and prevent chronic diseases?

The Nutrition for Precision Health study is trying to answer this question by studying how individual people respond to different foods. Nutrition for Precision Health is a partner of the All of Us Research Program. This is a large effort to speed up health research.

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What is the study researching?

Nutrition, or the foods we eat, can help prevent and fight conditions like high blood pressure, diabetes, stroke, and cancer.

But we all live in different environments and come from different cultures. Each of us is starting from a different place with our health. And everyone breaks down food differently.

The Nutrition for Precision Health study is researching how nutrition can be tailored to each person’s genes, culture, and environment to improve health.

Nutrition is not one-size-fits-all.

Who can join?

We plan to enroll 10,000 people from different backgrounds in the Nutrition for Precision Health study. Participants must be 18 years or older, speak English or Spanish, live near one of the study sites, and be enrolled in our partner program, the All of Us Research Program. Learn more about the All of Us Research Program at JoinAllofUs.org.

Research staff will work with people who are interested to see if the Nutrition for Precision Health study is a good fit for them. Research staff will talk with each person about their medical background and the study activities.

What would I do in the study?

If you choose to join the study, your participation will last about two weeks and include several steps:

1. Screening

You will first meet with research staff, virtually or in person, to determine if you are eligible. If you choose to take part in the study, you will give your consent.

2. First Study Visit

You will come to a study location to answer some questionnaires about your typical diet. You will also get instructions, wearable technology, and materials to use for at-home data collection.

3. At-home Data Collection

For the next 8 to 10 days, you will live your life as you normally do. You will complete questionnaires about the food you eat on some days and take pictures of your food on other days. You will use the wearable technology provided to you to gather other information. You will also collect a stool sample one time at home using a kit given to you at the first study visit.

4. Second Study Visit

You will visit a study location to complete a physical exam and provide biospecimens, like blood and saliva. You will also eat a test meal, which is like a smoothie. This helps us understand your body’s response to food. The second study visit takes 5 to 8 hours.

Study participants will be compensated up to $300 for time spent completing study activities.

After completing this study, you may be invited to take part in a follow-up study. In it, you would be eating three different diets provided by the study, each over two weeks. This follow-up study would require more of your time and include extra compensation.

Get Involved

We need help from people like you to learn how different people respond to different foods. These insights may pave the way for more tailored diets in the future. This could help people lead healthier lives.

If you are 18 years old or older, speak English or Spanish, and are enrolled in the All of Us Research Program, you may be eligible for the Nutrition for Precision Health study.

If you are not an All of Us participant, you can learn more about the All of Us Research Program at JoinAllofUs.org.

If you think you may be eligible and want to learn more, we would like to talk to you! Please contact a Nutrition for Precision Health study location near you.